What is the strongest weight loss prescription pill?

Obesity has become a significant public health concern in the United States, with recent statistics indicating that approximately 42.4% of adults are classified as obese, a figure that has been steadily rising over the past few decades.

For individuals struggling with obesity, weight loss can be a challenging journey, but appetite suppressants, including prescription weight loss pills, can offer valuable assistance. These medications work by reducing hunger and increasing feelings of fullness, making it easier for individuals to adhere to a calorie-restricted diet.

Read on to explore the strongest weight loss prescription pills and injections currently available, their effectiveness and how they can support those looking to achieve a healthier weight.

Available weight loss medications

When it comes to managing obesity, several prescription medications are available that can aid in weight loss. These weight loss medications work through various mechanisms, including appetite suppression and metabolic enhancement, providing individuals with additional support on their weight loss journey. Below, we outline some of the most notable weight loss prescription pills currently available:

Semaglutide (Wegovy, Ozempic)

Semaglutide is a GLP-1 receptor agonist that helps regulate appetite and food intake. Originally developed for diabetes management, it has shown significant weight loss results in clinical trials, making it a popular choice for obesity treatment.

Tirzepatide (Zepbound, Mounjaro)

Tirzepatide is a newer medication that works on multiple receptors to enhance insulin secretion and reduce appetite. Its dual-action mechanism has demonstrated promising results in weight loss and metabolic health.

Liraglutide (Saxenda)

Similar to semaglutide, liraglutide is another GLP-1 receptor agonist that promotes weight loss by decreasing hunger and increasing satiety. It is administered via daily injections and has been effective for many individuals.

Phentermine (Adipex, Suprenza)

Phentermine is one of the oldest weight loss medications and acts as an appetite suppressant. It is typically prescribed for short-term use and can help jumpstart weight loss efforts.

Phentermine-topiramate (Qsymia)

This combination medication includes phentermine and topiramate, which together enhance appetite suppression and promote feelings of fullness. Qsymia is often prescribed for individuals who need more robust support in their weight loss journey.

Naltrexone-bupropion (Contrave)

Contrave combines naltrexone, an opioid antagonist, and bupropion, an antidepressant, to help control cravings and reduce appetite. This medication targets the brain's reward system, making it effective for some individuals.

Setmelanotide (Imcivree)

Setmelanotide is specifically indicated for weight management in individuals with certain genetic disorders that cause obesity. It works by targeting the melanocortin-4 receptor, which plays a role in appetite regulation.

Orlistat (Xenical and Alli)

Orlistat is a lipase inhibitor that prevents the absorption of dietary fats in the intestines. Available in both prescription (Xenical) and over-the-counter (Alli) forms, it can be a helpful option for those looking to manage their weight through dietary changes.

Who is eligible for weight loss pills?

Weight loss pills are typically prescribed to individuals who are struggling with obesity and have not achieved significant weight loss through lifestyle changes alone, according to the Obesity Medicine Association. They explain that the eligibility criteria can vary based on specific medications, but generally, healthcare providers assess a patient's body mass index (BMI), overall health and any related medical conditions before recommending these medications.

To be eligible for weight loss pills, the Obesity Medicine Association notes that individuals usually need to have a BMI of 30 or higher, which classifies them as obese, or a BMI of 27 or higher with obesity-related health conditions, such as type 2 diabetes, hypertension or sleep apnea. Additionally, candidates should have made attempts to lose weight through diet and exercise without success. It's crucial for healthcare providers to evaluate each patient's unique situation, including potential risks and benefits, to determine the most appropriate treatment plan. Regular follow-ups and lifestyle modifications are often recommended alongside the use of weight loss medications to ensure the best outcomes for patients.

How do obesity drugs work?

Understanding how obesity drugs work is important for those considering medications as part of their weight loss journey since these drugs employ various mechanisms to help you with weight management — targeting different physiological processes to promote healthier body weight and improve metabolic health. Below are several key ways in which obesity drugs function:

• Appetite Suppression: Many obesity medications work by reducing feelings of hunger, helping individuals consume fewer calories. This effect can lead to significant weight loss when combined with a balanced diet.
• Increased Metabolic Rate: Some drugs enhance the body's metabolism, allowing it to burn calories more efficiently. This increased metabolic rate can contribute to weight loss even at rest.
• Blocked Fat Absorption: Certain medications, like orlistat, inhibit the enzymes responsible for breaking down dietary fats in the intestines, leading to reduced fat absorption and fewer calories being absorbed from meals.
• Hormone Regulation: Obesity drugs can influence hormones related to hunger and satiety, such as GLP-1 and leptin. Modulating these hormones can help regulate appetite and energy balance.
• Blood Sugar Regulation: Some weight loss medications also help improve insulin sensitivity and control blood sugar levels, which can be particularly beneficial for individuals with type 2 diabetes or metabolic syndrome.
• Gut Microbiome Effects: Emerging research suggests that certain obesity drugs may positively affect the gut microbiome, which plays a role in digestion and metabolism, potentially aiding in weight loss and improving overall health.

How to get prescription weight loss medication

Getting a prescription weight loss medication usually begins with a consultation with a healthcare provider. Platforms like Solvhealth offer convenient access to weight loss consultations and prescriptions for individuals looking to streamline this process — connecting patients with licensed healthcare professionals, Solvhealth simplifies the journey toward achieving a healthier weight through medication.

Find your perfect medical weight loss program

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